Product summary List Products



30 tablets
  • Clinically proven to relieve premenstrual syndrome
  • Contains a unique extract of Vitex agnus-castus (Chaste tree) that cannot be found in any other product
  • Practitioner product


    Premular® (Ze 440) is a natural medicine clinically proven for the symptomatic relief of premenstrual syndrome (PMS); including symptoms of irritability, anger, headache, bloating and breast tenderness. Vitex agnus castus (Chaste tree) has a long history of use for hormonal conditions and menstrual complaints. Premular provides a clinically trialled and highly effective tablet extract of Vitex agnus castus, an evidence-based chaste tree product for the management of PMS.

    Clinical resesarch:

    Premular is the only Vitex agnus-castus product to have demonstrated significant efficacy in clinical trials, including a double-blind placebo controlled trial published in the British Medical Journal. The trial showed a significant improvement in all PMS symptom scores for women taking Premular over a 3 month period. More than 50% of women treated with Premular during the study period
    experienced ?50% improvement in their PMS symptoms.

    Premular has demonstrated sustained relief, even after treatment has ceased. A multicentre randomised control trial showed that participants’ symptom scores
    remained 21.7% (p<0.001) below baseline, 3 cycles post-treatment.

    In vitro research has demonstrated Premular’s dopaminergic action8 and several clinical trials have shown its effect for the relief of PMS. A newly published study has also shown that the dose used in Premular is the most effective for symptom relief, with no improvement when a larger dose was administered.

    Due to the evidence supporting Premular’s use and efficacy, it is the only Vitex product to be assigned a ‘ well established use’ status by the EMEA.


    Easy, once daily dose. Excellent tolerability. Very low incidence of adverse effects, comparable to placebo.


    One tablet daily with water, at about the same time each day, preferably an hour before or after meals. Consistent symptom improvement expected after 3 months treatment.



    Premular contains a specific extract of Vitex agnus-castus (Chaste tree) that has been examined in a number of clinical trials. This extract, referred to as Ze 440 in the scientific literature, is produced in Switzerland according to patented production methods. Such processes ensure consistently high quality from batch to batch.

    Related Products