Product summary List Products
Main ingredients: Pancreatine | Protease | Lipase | Amylase | Bromelain | Trypsin


D.E.F. Digestive Enzyme

180 tablets
Access if prescribed


May be of assistance in the following:
- Maintenance of healthy digestive function
- Supporting pancreatic health

The active ingredients in Orthoplex D.E.F. Digestive Enzyme Formula, when appropriately prescribed, may assist patients suffering from the above conditions. This statement does not imply or make a claim for a cure of these disorders. The use of Orthoplex D.E.F. Digestive Enzyme Formula should be based on the published and relevant scientific and clinical data for each condition.

The product is gluten free, glucose free and lactose free.


It has been demonstrated that pancreatic enzymes may have a beneficial effect on expression of intestinal allergic inflammation. Application of pancreatic enzymes has been found to significantly reduce clinical symptoms.

The pineapple protease, bromelain, selectively inhibits the biosynthesis of proinflammatory prostaglandins, apparently by indirect action. It has been suggested that bromelain acts on the prostaglandin synthetic pathway at a site different from that affected by the non-steroidal anti-inflammatory drugs. It is postulated that bromelain acts further down the arachidonate cascade at the thromboxane synthetase step. Circumstantial evidence suggests that bromelain inhibits the synthesis of the 'proinflammatory' prostaglandins without affecting the 'anti-inflammatory' ones.

Each tablet contains:

  • Pancreatin 4:1 - 200 mg
  • Equivalent to:
    • Protease 280 BP units
    • Lipase 4000 BP units
    • Amylase 4800 BP units
    • Bromelain 100 mg
    • Trypsin 30 mg

Excipients: Calcium hydrogen phosphate, povidone, crospovidone, microcrystalline cellulose, magnesium stearate, hypromellose, macrogol 400, glucose

Suggested Dosage:

Adults: 1 - 2 tablets directly after each meal or as prescribed

Cautions and Contradictions:

Contains Bromelain, sourced from pineapples; use with caution in patients sensitive to pineapples. Contains ingredients of porcine origin.

Animal pancreatin vs Vegetarian pancreatin:

Porcine pancreatin has higher lipase activity than vegetarian pancreatin. This may be more beneficial for those with problems with lipid digestion. Porcine lipase has been the therapeutic standard for several decades and will continue to be the treatment of choice in pancreatic exocrine insufficiency.

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