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Summary:

Orthoplex Multiflora is a comprehensive probiotic containing over 24 billion live bacteria per capsule. Multiflora may be of assistance in conditions associated with diarrhoea, antibiotic use, candida and poor immune function.

Indications:
  • Helps support healthy intestinal flora
  • May help to support gastro-intestinal health
  • Relief or treatment of diarrhoea
  • For the symptomatic relief of medically diagnosed irritable bowel syndrome
  • May assist in the management of medically diagnosed irritable bowel syndrome
  • May help to reduce side effects of antibiotic use
  • May help maintain a healthy immune system

There are numerous species and strains of bacteria that reside in and are essential for normal gastrointestinal function. Certain species of these bacteria have been consistently promoted to restore the balance of beneficial bacteria in the human gastrointestinal tract.

Due to the large number of different species present throughout the GI tract, the use of a broad based spectrum flora complex, containing a large number of species may be more successful at restoring bacterial balance than a single probiotic.

Irritable Bowel Syndrome (IBS)
Probiotics may have a role in alleviating some of the symptoms of IBS, a condition for which currently evidence of efficacy of drug therapies is weak (5). Probiotics may improve symptoms of IBS and can be used as a supplement to standard therapy (6).

Clinical Trial: The intestinal permeability is increased in patients with diarrhoea-predominant irritable bowel syndrome (D-IBS). Treatment with probiotics significantly decreased the mean global IBS scores compared with the baseline scores (9.62 +/- 1.05 vs. 7.64 +/- 1.24, P < 0.001). In conclusion, multi-strain probiotic treatment improved mucosal barrier function in D-IBS patients (7).

Reducing side effects of antibiotic use
One of the side effects of antimicrobial therapy is a disturbance of the intestinal microbiota potentially resulting in antibiotic associated diarrhea. Clinical Trial: Moreover, the intake of a multispecies probiotic significantly reduced diarrhoea-like bowel movements in healthy volunteers receiving amoxicillin (6). From this it can be concluded that probiotics containing multiple species of Lactobacilli and Bifidobacteria may be more effective in preventing dysbiosis influenced by ceftriaxone treatment than other probiotic preparations.

Maintaining a healthy immune system
The intake of probiotic bacteria for at least 3 months significantly shortened common cold episodes by almost 2 days and reduced the severity of symptoms. A significantly higher enhancement of cytotoxic plus T suppressor cells (CD8+) and a higher enhancement of T helper cells (CD4+) was observed in the probiotic-treated group. Fecal Lactobacilli and Bifidobacteria increased significantly after probiotic supplementation (9).

References
1. Monostrain, multistrain and multispecies probiotics - A comparison of functionality and efficacy. Timmerman, HM et al. s.l. : International Journal of Food Microbiology, 2004, Vol. 96.
2. The effect of a multispecies probiotic on the composition of the faecal microbiota and bowel habits in chronic obstructive pulmonary disease patients treated with antibiotics. Koning CJ, Jonkers D, Smidt H, Rombouts F, Pennings HJ, Wouters E, Stobberingh E, Stockbrügger R. s.l. : Br J Nutr. 2009. , 2009, Vols. Dec 21:1-9.
3. Mechanisms of action of probiotics: recent advances. Ng SC, Hart AL, Kamm MA, Stagg AJ, Knight SC. 2, s.l. : Inflamm Bowel Dis., 2009, Vol. 15.
4. Antagonistic activities of lactobacilli and bifidobacteria against microbial pathogens. AL, Servin. s.l. : FEMS Microbiol Rev, 2004.
5. Survival and therapeutic potential of probiotic organisms with reference to Lactobacillus acidophilus and Bifidobacterium spp. Kailasapathy K, Chin J. s.l. : Immunology and Cell Biology., 2000, Vol. 78.
6. A systematic review and meta-analysis: probiotics in the treatment of irritable bowel syndrome. Hoveyda N, et al. 1, s.l. : BMC Gastroenterology, 2009, Vol. 9.
7. Efficacy of probiotics in irritable bowel syndrome: a meta-analysis of randomized, controlled trials. Nikfar S, et al. 12, s.l. : Dis Colon Rectum., 2008, Vol. 51.
8. Li, L. et al. Clinical trial: effect of active lactic acid bacteria on mucosal barrier function in patients with diarrhoea-predominant irritable bowel syndrome. : s.n.
9. CLINICAL USEFULNESS OF PROBIOTICS IN INFLAMMATORY BOWEL DISEASES. Mach, T. s.l. : Department of Gastroenterology, 2006.

 

Dosage:

Adults: Take 1 capsule per day or as prescribed.

 

Active Ingredients:

Extracts equivalent to:
  • Lactobacillus acidophilus 5 billion organisms
  • Lactobacillus casei 500 million organisms
  • Lactobacillus plantarum 5 billion organisms
  • Lactobacillus rhamnosus 5 billion organisms
  • Lactobacillus gasseri 100 million organisms
  • Lactobacillus delbrueckii ssp bulgaricus 100 million organisms
  • Streptococcus thermophilus 500 million organisms
  • Bifidobacterium longum 3 billion organisms
  • Bifidobacterium breve 2 billion organisms
  • Bifidobacterium lactis 3 billion organisms
  • Lactobacillus salivarius 400 million organisms
  • Bifidobacterium infantis 400 million organisms

Excipients: Microcrystalline cellulose, silica colloidal anhydrous, ascorbic acid.
Orthoplex Multiflora is gluten and glucose free - suitable for vegetarians.

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