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Orthoplex

MagOpti cell

300 g
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Summary:

Orthoplex MagOpti cell is a potent magnesium supplement that may be beneficial for nervous tension, stress, anxiety and relief of muscular cramps and spasms. MagOpti cell provides a potent array of vitamins, nutrients and minerals per serve, and has shown positive benefits in conditions associated with cardiovascular health, mitochondrial energy production and magnesium deficiency.

Magnesium is the fourth most abundant mineral in the body and plays a crucial role in biochemistry, being involved in over 300 metabolic reactions.

Nervous tension, Stress & Anxiety
Magnesium deficiency can present with nervous system dysfunction including stress, aggressiveness, [6] anxiety,[7] poor concentration, headaches [8] and even depression.[9]

Magnesium supplementation to correct magnesium deficiency may therefore alleviate nervous tension, stress, anxiety and depression. Magnesium supplementation has also been found beneficial in the support of epilepsy sufferers.[10]

The B vitamins are required for optimal nervous system functioning. They may complement magnesium supplementation in supporting the nervous system and adrenal glands.

Muscle Cramps & Spasms
Magnesium concentrates in the muscles and is required for ATP production and the transmission of nerve impulses to the muscles. Magnesium deficiency has been associated with muscle cramps, low bone mineral density, reduced muscle strength, muscle weakness and fatigue.

A randomised, double blind, placebo controlled crossover pilot study showed malic acid in combination with magnesium to reduce muscle pain and tenderness in fibromyalgia patients.[11]

Oral supplementation of creatine increases muscle supply of free creatine and creatine phosphate, a high-energy phosphagen. Creatine levels have been found to be low in those suffering from fibromyalgia.[12]

Cardiovascular Health
Magnesium deficiency may contribute to cardiovascular dysfunction such as hypertension and coronary artery disease. Clinical evidence has suggested that magnesium influences vascular tone and may play an important role in regulating blood pressure by having a direct effect upon the relaxation capability of vascular smooth muscle cells.[13]

As potassium plays an essential role in the membrane potential of cardiac muscle, it may help to regulate the contraction of the cardiac muscle. Low potassium levels may lead to alterations in cardiac rate, rhythm and conduction.[14] A randomised, placebo controlled trial showed that supplementation of potassium in 150 men and women with high blood pressure resulted in a substantial reduction in systolic blood pressure.[15]

Mitochondrial Energy Production
Magnesium is required for energy production and ATP exists in many cells as an ATP-Mg complex. Creatine is an endogenous amino acid, which concentrates in the skeletal muscles and improves the condition of muscle fibres.[16]

The creatine kinase system is involved in the rapid transport of high energy phosphates from the mitochondria to sites of maximal energy requirements such as myofibrils and sarcolemmal ion pumps.[17]
Creatine may also improve muscle tone and lean muscle mass in weight training individuals.

Malic acid is an intermediate endogenous acid in the Krebs cycle, and is therefore involved in energy production. Supplementation of malic acid has been shown to enhance physical working capacity and stimulate productive bioenergetic processes.

References
1. Seelig, M., Consequences of magnesium deficiency on the enhancement of stress reactions; preventive and therapeutic implications (a review).
J Am Coll Nutr., 1994. 13(5): p. 429-46.
2. Roffe, C., Sills, S., Crome, P., Jones, P., Randomized, cross-over, placebo controlled trial of magnesium citrate in the treatment of chronic persistent
leg cramps. Med Sci Monit, 2002. 8(5): p. 326-30.
3. Jee, S., et al., The effect of magnesium supplementation on blood pressure: a meta-analysis of randomized controlled trials.
Am J Hypertens., 2002. 15(8): p. 691-6.
4. Reda, E., et al., The carnitine system and body composition. Acta Diabetol., 2003. 40: p. 106-13.
5. Cowan, J., BioMetals, 2002. 15: p. 225-35.
6. Werbach, M., Nutritional influences on aggressive behavior. Journal of Orthomolecular Medicine, 1995. 7(1).
7. Grimaldi, B., The central role of magnesium deficiency in Tourette's syndrome: causal relationships between magnesium deficiency,
altered biochemical pathways and symptoms relating to Tourette's syndrome and several reported comorbid conditions.
Med Hypotheses, 2002. 58(1): p. 47-60.
8. Mauskop, A., et al., Intravenous magnesium sulfate relieves cluster headaches in patients with low serum ionized magnesium levels.
Headache., 1995. 35(10): p. 597-600.
9. Webb, W., et al., Electrolyte and fluid imbalance: Neuropsychiatric manifestations. Psychosomatics., 1981. 22(3): p. 199-203.
10. Doretto, M., Simoes, S., Paiva, AM., Osorio-Neto, E., Zinc, magnesium and copper profiles in three experimental models of epilepsy.
Brain Res., 2002. 956(1): p. 166-72.
11. Russell, I., Michalek, JE., Flechas, JD., Abraham, GE., Treatment of fibromyalgia syndrome with Super Malic: a randomized, double blind, placebo
controlled, crossover pilot study. J Rheumatol., 1995. 22(5): p. 953-8.
12. Bengtsson, A., Henriksson, KG., Larsson, J., Reduced high-energy phosphate levels in the painful muscles of patients with primary fibromyalgia.
Arthritis Rheum., 1986. 29(7): p. 817-21.
13. Rosanoff, A., [Magnesium and hypertension]. Clin Calcium, 2005. 15(2): p. 255-60.
14. Modern Nutrition in Health and Disease. 10th ed, ed. M. Shils, et al. 2005, Baltimore, USA.: Lippincott Williams & Wilkins.
15. Gu, D., et al., Effect of potassium supplementation on blood pressure in Chinese: a randomized, placebo-controlled trial.
Journal of Hypertension., 2001. 19(7): p. 1325-1331.
16. Sipila, I., et al., Supplementary creatine as a treatment for gyrate atrophy of the choroid and retina.
New England Journal of Medicine., 1981. 304(15): p. 867-870.
17. Spindler, M., et al., Creatine kinase-deficient hearts exhibit increased susceptibility to ischemia-reperfusion injury and impaired calcium homeostasis.
Am J Physiol Heart Circ Physiol., 2004. 287(3): p. H1039-45.
18. Dunaev, W., et al., Effect of malic acid salts on physical work capacity and its recovery after exhausting muscular activity.
Farmakol Toksikol., 1988. 51(3): p. 21-25.
19. Lim, D., McKay, M., Food-drug interactions. Drug Information Bull, 1995. 15(2).
20. Holt, G., Food & Drug Interactions. 1998, Chicago: Precept Press.


Orthoplex MagOpti cell is gluten, lactose, sugar and glucose free - suitable for vegetarians.

 

Dosage:

Adults: Take 6.5 g (1 3/4 5 mL metric spoonful) daily in water or as prescribed. Recommended with food.

 

Precautions:

Should not be taken within two hours of antibiotic medications, as calcium, zinc, magnesium and manganese may reduce absorption of antibiotics. Use magnesium with caution in people with renal failure. High doses of creatine are contraindicated in kidney failure.

 

Active Ingredients:

Extracts equivalent to:
  • Magnesium amino acid chelate 1.3 g
  • Magnesium citrate 647 mg
  • Magnesium orotate dihydrate 457 mg
  • Magnesium phosphate 145 mg
  • Total elemental magnesium 310 mg
  • Potassium citrate 221 mg
  • Potassium phosphate 174 mg
  • Total elemental potassium 130 mg
  • Calcium pantothenate 163.8 mg
    • Equivalent pantothenic acid 150 mg
  • Thiamine hydrochloride 30 mg
  • Pyridoxal-5-phosphate 10 mg
    • Equivalent pyridoxine 6.8 mg
  • Nicotinamide 50 mg
  • Riboflavin 10 mg
  • Selenomethionine 625 µg
    • Equivalent selenium 25 µg
  • Taurine 500 mg
  • Glutamine 500 mg
  • Folic acid 500 µg
  • Cyanocobalamin 400 µg
  • Ascorbic acid 200 mg
  • L-carnitine 70 mg
  • Creatine monohydrate 1 g
  • Zinc amino acid chelate 25mg
    • Equivalent zinc 5 mg
  • Manganese amino acid chelate 10 mg
    • Equivalent manganese 1 mg
  • Chromium nicotinate 500 µg
    • Equivalent chromium 50 µg

Excipients: Malic acid, Stevia rebaudiana leaf extract dry, Trusil fruit punch flavour.

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